Reaktion #164024

ord-2717b3f8bfa84c05a7accb02e8c22307

Reaktionsgleichung

CC(C)(C)[C@H](N)C(=O)O
L-tert-leucine
CC(C)OC(C)C
diisopropyl ether
→
CC(C)(C)[C@@H](N)C(=O)O
D-tert-leucine
Ausbeute 90.0%

Edukte

CC(C)(C)[C@H](N)C(=O)O
L-tert-leucine
CC(C)OC(C)C
diisopropyl ether

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto remove any traces of dibenzoyl-d-tartaric acid
  2. 2
    Einengenwas concentrated under reduced pressure at 55° C
  3. 3
    SonstigeThe residue obtained
  4. 4
    Filtrationfiltered

Vorschrift

The filtrate obtained at dibenzoyl-d-tartrate salt stage (step.ii), was treated with a small amount of diisopropyl ether to remove any traces of dibenzoyl-d-tartaric acid and was concentrated under reduced pressure at 55° C. The residue obtained was stirred with small amount of acetone and filtered to obtain D-tert-leucine as a colorless solid (90% yield, 98.8% D-tert-leucine and 1.2% L-tert-leucine).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08835676B2uspto-grants-2014_09