Reaktion #163993

ord-e50f37a17a0c431eb0ab23a5be0457ad

Reaktionsgleichung

Cc1c(Br)cccc1SCc1ccccc1
Intermediate 24
Cc1c(Br)cccc1SCc1ccccc1
1-Benzylsulfanyl-3-bromo-2-methyl-benzene
O=C1CCCN1
pyrrolidin-2-one
Cc1c(SCc2ccccc2)cccc1N1CCCC1=O
1-(3-Benzylsulfanyl-2-methyl-phenyl)-pyrrolidin-2-one

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product (14.6 g) was used without purification in the next step

Vorschrift

Intermediate 24 (14.08 g, 48 mmol) and pyrrolidin-2-one (4.9 g, 57.6 mmol) were converted to intermediate 25 as described in example 1; 1.5). The crude product (14.6 g) was used without purification in the next step.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08835653B2uspto-grants-2014_09