Reaktion #163981

Reaktionsgleichung

NH4Cl

1,3-dibromo benzene

ethyl iodide

LDA

→

1,3-Dibromo-2-ethyl-benzene

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA three necked round-bottom flask was purged with argon
2. 2
   Sonstigedid not rise above −65° C
3. 3
   workup.STIRRINGstirred vigorously for 20 min
4. 4
   ExtraktionTwo times extraction with DCM yielded colorless oil (167 g) which
5. 5
   Sonstigewas used in the next step without further purification

Vorschrift

A three necked round-bottom flask was purged with argon and then filled with dry THF (1.2 l), 1,3-dibromo benzene (121 g, 0.514 mol) and ethyl iodide (95.4 g, 0.611 mol). The mixture was cooled to −78° C. and LDA (64.2 g, 0.697 mol) (2 M in THF/n-heptane/ethyl benzene) was added slowly in a way that the temperature did not rise above −65° C. After stirring for 2.75 h the reaction was poured onto 1 l sat. aq. NH4Cl solution and stirred vigorously for 20 min. Two times extraction with DCM yielded colorless oil (167 g) which was used in the next step without further purification.

Quelle