Reaktion #163972

Reaktionsgleichung

Potassium sodium 2,3-dihydroxybutanedioate tetrahydrate

Compound 21

N-(5-tert-butyl-3,3-dimethyl-2-oxo-2,3-dihydrobenzofuran-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

2-MeTHF

Lithium aluminum hydride

→

title compound

N-(2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Lösungsmittel

MTBE

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 3-neck 50 mL round bottom flask was equipped with magnetic stirrer
2. 2
   workup.STIRRINGThe resulting solution was stirred for 15 minutes
3. 3
   SonstigeThe organic layer was separated
4. 4
   workup.ADDITIONby adding Tartaric acid
5. 5
   ExtraktionThe aqueous layer was extracted with MTBE
6. 6
   EinengenThe organic layer was concentrated
7. 7
   Sonstigedried under high vacuum

Vorschrift

A 3-neck 50 mL round bottom flask was equipped with magnetic stirrer, nitrogen bubbler and thermocouple. Compound 21 (514 mg, 1.27 mmol) and 2-MeTHF (4 mL) are charged to the flask. The reaction mixture was stirred at room temperature. Lithium aluminum hydride (204 mg, 6.6 mmol) was added as solid until 100% conversion is achieved, which was monitored using HPLC. Potassium sodium 2,3-dihydroxybutanedioate tetrahydrate salt (50 mL of a 400 g/L solution) and MTBE (50 mL) were added to the reaction mixture. The resulting solution was stirred for 15 minutes and then let sit for 15 min. The organic layer was separated and the pH of the aqueous layer was adjusted to a pH of about 6-7 by adding Tartaric acid. The aqueous layer was extracted with MTBE. The organic layer was concentrated and dried under high vacuum to provide the title compound as an off-white powder. The 1H-NMR spectrum was consistent with that reported above.

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