Reaktion #163623

ord-480a73fd8bd943f69be95eeb87f4d042

Reaktionsgleichung

O=C(Cl)c1cccc([N+](=O)[O-])c1
3-nitrobenzoylchloride
CCOC(=O)C1CCNCC1
ethyl isonipecotate
CCOC(=O)C1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1
1-[4-(ethoxycarbonyl)piperidinocarbonyl]-3-nitrobenzene
→
CCOC(=O)C1CCN(C(=O)c2cccc(N)c2)CC1
3-[4-(ethoxycarbonyl)piperidinocarbonyl]aniline

Edukte

O=C(Cl)c1cccc([N+](=O)[O-])c1
3-nitrobenzoylchloride
CCOC(=O)C1CCNCC1
ethyl isonipecotate
CCOC(=O)C1CCN(C(=O)c2cccc([N+](=O)[O-])c2)CC1
1-[4-(ethoxycarbonyl)piperidinocarbonyl]-3-nitrobenzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewere reacted

Vorschrift

In like manner to the preparation of 3-(N-morpholinocarbonyl)aniline, 3-nitrobenzoylchloride and ethyl isonipecotate were reacted to prepare 1-[4-(ethoxycarbonyl)piperidinocarbonyl]-3-nitrobenzene which underwent hydrogenation to provide 3-[4-(ethoxycarbonyl)piperidinocarbonyl]aniline.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08835430B2uspto-grants-2014_09