Reaktion #163566

Reaktionsgleichung

3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine

Benzoic acid

→

3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine benzoic acid salt

Ausbeute 69.5%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe white precipitate that formed
2. 2
   Filtrationwas filtered
3. 3
   Waschenwashed with toluene (3×30 mL)

Vorschrift

To 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine (15.52 g, 63.3 mmol) was added toluene (75 mL). Benzoic acid (7.73 g, 63.3 mmol) was added in one portion. The reaction mixture was stirred for 18 hours and the white precipitate that formed was filtered and washed with toluene (3×30 mL) to give 3-hydroxy-3-[(1-ethoxyethyl)mercaptomethyl]quinuclidine benzoic acid salt (16.15 g, 44.0 mmol, 69%) as a white solid containing 10% toluene by weight.

Quelle