Reaktion #163453

Reaktionsgleichung

sulfamic acid

sodium chlorite

5-Isopropyl-2-methoxybenzaldehyde

→

title compound

5-isopropyl-2-methoxybenzoic acid

Lösungsmittel

water

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe acetone was removed
2. 2
   Extraktionthe mixture was extracted with Et2O
3. 3
   TrocknenThe organic layer was dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

5-Isopropyl-2-methoxybenzaldehyde (2.8 g, 15.7 mmol) was dissolved in acetone (40 mL). To this solution was added sulfamic acid (2.29 g, 23.57 mmol) and sodium chlorite (1.71 g, 18.85 mmol) in water (40 mL). The mixture was stirred at rt in an open flask for 12 hrs. The acetone was removed and the mixture was extracted with Et2O. The organic layer was dried over MgSO4, filtered and concentrated to afford the title compound. MS (DCI/NH4+) m/z 212 (M+NH4)+.

Quelle