Reaktion #163377

Reaktionsgleichung

1-ethoxy-4-ethynylbenzene

N-(4-iodophen-ethyl)propionamide

→

N-(4-((4-Ethoxyphenyl)ethynyl)phenethyl)propionamide

Lösungsmittel

water

sec-butylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture is partitioned between DCM and water
2. 2
   SonstigeThe solvent of the organic layer is evaporated in vacuo
3. 3
   Sonstigethe residue is purified by HPLC (MeOH/H2O/NH3)

Vorschrift

150 mg (1.03 mmol) 1-ethoxy-4-ethynylbenzene, 327 mg (1.08 mmol) N-(4-iodophen-ethyl)propionamide (I47.2) and 36 mg (0.05 mmol) bis(triphenylphosphine)dichloro-palladium in 2.0 mL water and 1.5 mL sec-butylamine are stirred at r.t. over night and for additional 4 h at 30° C. The reaction mixture is partitioned between DCM and water. The solvent of the organic layer is evaporated in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).

Quelle