Reaktion #163356

Reaktionsgleichung

2-(4-iodophenyl)-1,1-dimethyl-ethyl-carbamic acid tert-butyl ester

HCl

→

2-(4-Iodophenyl)-1,1-dimethyl-ethylamine

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent is removed in vacuo
2. 2
   Sonstigethe residue is purified by HPLC (MeOH/H2O/NH3)

Vorschrift

To 1.10 g (2.93 mmol) 2-(4-iodophenyl)-1,1-dimethyl-ethyl-carbamic acid tert-butyl ester (I52.9) in 10 mL MeOH are added 7.04 mL (8.80 mmol) HCl (1.25M in MeOH). The mixture is stirred at 50° C. for 3 h. The solvent is removed in vacuo and the residue is purified by HPLC (MeOH/H2O/NH3).

Quelle