Reaktion #163313

Reaktionsgleichung

cyclopentanol

5-bromo-2-chloro-pyrimidine

NaH

→

5-Bromo-2-cyclopentyloxy-pyrimidine

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removing of the cooling bath the reaction mixture
2. 2
   SonstigeThe reaction is quenched by the addition of water
3. 3
   SonstigeThe solvent is removed under vacuo
4. 4
   workup.DISSOLUTIONthe residue is dissolved in DCM
5. 5
   Waschenwashed with water
6. 6
   Trocknendried with MgSO4
7. 7
   SonstigeThe solvent is removed under reduced pressure
8. 8
   SonstigeThe crude product is used without further purification

Vorschrift

36.3 μL (0.40 mmol) cyclopentanol and 38.7 mg (0.20 mmol) 5-bromo-2-chloro-pyrimidine are added to 1.5 mL dioxane and cooled down to 0° C. Then the reaction mixture is charged with 24.0 mg NaH. After removing of the cooling bath the reaction mixture is stirred at r.t. over night. The reaction is quenched by the addition of water. The solvent is removed under vacuo and the residue is dissolved in DCM, washed with water and dried with MgSO4. The solvent is removed under reduced pressure. The crude product is used without further purification.

Quelle