Reaktion #163122

Reaktionsgleichung

2,5,6-trifluoronicotinonitrile

triethylamine

5-methyl-1H-pyrazol-3-amine

→

title compound

Ausbeute 29.7%

2,5-Difluoro-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

Ausbeute 29.7%

Lösungsmittel

ACN

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationwas filtered
2. 2
   WaschenThe resulting solid was washed with cold ACN
3. 3
   Sonstigedried
4. 4
   Sonstigecollected

Vorschrift

To a solution of 2,5,6-trifluoronicotinonitrile (1.0 g, 6.3 mmol) and triethylamine (0.83 g, 8.2 mmol) in ACN (30 ml) at 0° C. was added 5-methyl-1H-pyrazol-3-amine (0.67 g, 6.9 mmol). The reaction was stirred at 0° C. for 1 hour, at which point the reaction was filtered. The resulting solid was washed with cold ACN, dried and collected to give the title compound (0.44 g, 29%). MS: Calcd.: 235. Found: [M+H]+ 236.

Quelle