Reaktion #163101

Reaktionsgleichung

5-isopropoxy-1H-pyrazol-3-amine

2,6-dichloro-5-fluoronicotinonitrile

triethylamine

→

title compound

Ausbeute 50.0%

2-Chloro-5-fluoro-6-(5-isopropoxy-1H-pyrazol-3-ylamino)nicotinonitrile

Ausbeute 50.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprecipitated
2. 2
   FiltrationThe resulting solid was filtered
3. 3
   Waschenwashed with hexanes (100 ml)

Vorschrift

A solution of 5-isopropoxy-1H-pyrazol-3-amine (0.96 g, 6.8 mmol), 2,6-dichloro-5-fluoronicotinonitrile (1.3 g, 6.8 mmol), and triethylamine (0.9 g, 8.8 mmol) in THF (30 ml) was heated to 60° C. for 4 days, and then cooled to 25° C., at which point the product precipitated. The resulting solid was filtered and washed with hexanes (100 ml) to give the title compound (1.0 g, 50%). MS: Calcd.: 295. Found: [M+H]+ 296.

Quelle