Reaktion #1629

ord-dc474815e92e4518a4bce138d4d23348

Reaktionsgleichung

CCCCOP(=O)(CCCOCc1ccccc1)COS(=O)(=O)c1ccc(Cl)cc1
3-benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl ester
C[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
(R)-2-(4-hydroxyphenyl)-1-methylethylcarbamic acid, t-butyl ester
→
CCCCO[P@](=O)(CCCOCc1ccccc1)COc1ccc(CC(C)NC(=O)OC(C)(C)C)cc1
title compound
CCCCO[P@](=O)(CCCOCc1ccccc1)COc1ccc(CC(C)NC(=O)OC(C)(C)C)cc1
(R)-4-(2-t-Butoxycarbonylaminopropyl)phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl ester

Edukte

CCCCOP(=O)(CCCOCc1ccccc1)COS(=O)(=O)c1ccc(Cl)cc1
3-benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl ester
C[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
(R)-2-(4-hydroxyphenyl)-1-methylethylcarbamic acid, t-butyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude product was purified by chromatography
  2. 2
    Wascheneluting with dichloromethane containing 3% methanol
  3. 3
    Sonstigeto give an oil

Vorschrift

The title compound was prepared from 3-benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl ester and (R)-2-(4-hydroxyphenyl)-1-methylethylcarbamic acid, t-butyl ester according to the method described in Procedure 24. The crude product was purified by chromatography, eluting with dichloromethane containing 3% methanol, to give an oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05726165uspto-grants-1998_03