Reaktion #162867

Reaktionsgleichung

Compound 8

(2S)-tert-butyl 2-(4-(4′-(2-((3S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole-1-carboxylate

water

→

(2S)-2-(4-(4′-(2-((3S)-2-azabicyclo[2.2.1]heptan-3-yl)-1H-imidazol-4-yl)biphenyl-4-yl)-1H-imidazol-2-yl)octahydro-1H-indole

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeResulting
2. 2
   Sonstigereaction
3. 3
   TemperaturThe resulting slurry was cooled to RT
4. 4
   FiltrationFiltration of the slurry
5. 5
   Sonstigeafforded a solid
6. 6
   Waschenwashed with 15 ml acetone
7. 7
   Sonstigedried directly
8. 8
   Sonstigeused in the next reaction

Vorschrift

Compound 8 were taken in 9 ml methanol; 1 ml Conc. HCL and 0.2 ml water was added. Resulting reaction was stirred for 5 h at 50° C. (oil bath temp) completed, after completion of the reaction monitor by HPLC. The resulting slurry was cooled to RT and held with agitation for about 1H. Filtration of the slurry afforded a solid; washed with 15 ml acetone dried directly used in the next reaction.

Quelle