Reaktion #162760

Reaktionsgleichung

Intermediate 6a

4-Nitro-1-p-tolyl-1H-pyrazole

→

title compound

Ausbeute 86.0%

4-Amino-1-p-tolyl-1H-pyrazole

Ausbeute 86.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was then filtered through Celite
2. 2
   Waschenwashing with ethanol
3. 3
   Sonstigeevaporated to dryness
4. 4
   SonstigeThe residue was purified by FCC
5. 5
   Wascheneluting with 0-10% MeOH in DCM

Vorschrift

Intermediate 6a (212 mg, 1.04 mmol) was dissolved in ethanol (20 mL) then hydrogenated over 10% palladium on carbon for 4 h under hydrogen atmosphere. The mixture was then filtered through Celite, washing with ethanol, and evaporated to dryness. The residue was purified by FCC, eluting with 0-10% MeOH in DCM, to give the title compound as a pale brown solid (154 mg, 86%). LCMS (Method 3): Rt 1.92 min, m/z 174.1 [MH−].

Quelle