Reaktion #162633

Reaktionsgleichung

3-(2-chloro-6-trifluoromethyl-pyrimidin-4-yl)-8-oxa-3-aza-bicyclo[3.2.1]octane

3-(2-Chloro-6-trifluoromethyl-pyrimidin-4-yl)-8-oxa-3-aza-bicyclo[3.2.1]octane

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

→

title compound

Ausbeute 86.0%

4-[4-(8-Oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-6-trifluoromethyl-pyrimidin-2-yl]-phenylamine

Ausbeute 86.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor the preparation of 6

Vorschrift

The title compound was prepared in 86% yield from 3-(2-chloro-6-trifluoromethyl-pyrimidin-4-yl)-8-oxa-3-aza-bicyclo[3.2.1]octane (63) and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, using the general procedure from scheme 2 for the preparation of 6. MS (ES+): 351.2 (M+H)+.

Quelle