Reaktion #1624

Reaktionsgleichung

4-(2-t-Butoxycarbonylaminoethyl)phenoxymethylphosphonic acid, diethyl ester

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title compound

4-(2-Aminoethyl)phenoxymethylphosphonic acid, diethyl ester

Lösungsmittel

methylene chloride

trifluoracetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe solution was concentrated under reduced pressure and product
2. 2
   Sonstigedried under in vacuo
3. 3
   Extraktionextracted with dichloromethane containing a small proportion of methanol (5×100 ml)
4. 4
   TrocknenThe combined organic layers were dried over sodium sulfate
5. 5
   Sonstigeevaporated to dryness

Vorschrift

4-(2-t-Butoxycarbonylaminoethyl)phenoxymethylphosphonic acid, diethyl ester (2.856 g, 9.95 mMol) in methylene chloride (300 ml) and trifluoracetic acid (16 ml) was stirred at room temperature for 5 h. The solution was concentrated under reduced pressure and product dried under in vacuo. The trifluoacetic acid salt was neutralized with aqueous sodium carbonate and extracted with dichloromethane containing a small proportion of methanol (5×100 ml). The combined organic layers were dried over sodium sulfate and evaporated to dryness to give the title compound as a pale yellow gum.

Quelle