Reaktion #1619808

Reaktionsgleichung

1-N-glycidyl-2-methylbenzimidazole

3-(4-tetrahydropyridinyl)indole

→

titled compound

Ausbeute 9.0%

1-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-3-(2-methyl-benzoimidazol-1-yl)-propan-2-ol

Ausbeute 9.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo
2. 2
   Sonstigethe product purified by flash silica gel chromatography (10% methanol in ethyl acetate)

Vorschrift

A methanolic solution of 1-N-glycidyl-2-methylbenzimidazole (0.64 g, 3.4 mmole) from example 7 and 3-(4-tetrahydropyridinyl)indole (0.67 g, 3.4 mmole) was refluxed under nitrogen for 24 hours. The reaction mixture was concentrated in vacuo and the product purified by flash silica gel chromatography (10% methanol in ethyl acetate) to afford the titled compound as a pale yellow colored solid (0.11 g, 9% yield). Treatment with a 0.25M ethanolic solution of fumaric acid (0.5 equivalents) gave the required product as a yellow colored solid. The product was recrystallized from ethanol.

Quelle