Reaktion #1619807

Reaktionsgleichung

1-N-glycidylindole

3-(4-tetrahydropyridinyl)indole

→

titled compound

Ausbeute 47.6%

1-Indol-1-yl-3-[4-(1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-propan-2-ol

Ausbeute 47.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo
2. 2
   Sonstigethe product purified by flash silica gel chromatography (ethyl acetate)

Vorschrift

A methanolic solution of 1-N-glycidylindole (0.52 g, 3.0 mmole) from example 4 and 3-(4-tetrahydropyridinyl)indole (0.59 g, 3.0 mmole) was refluxed under nitrogen for 24 hours. The reaction mixture was concentrated in vacuo and the product purified by flash silica gel chromatography (ethyl acetate) to afford the titled compound as a yellow colored solid (0.53 g, 47% yield). Treatment with a 0.25M ethanolic solution of fumaric acid (0.5 equivalents) gave the required product as a yellow colored solid. The product was recrystallized from ethanol.

Quelle