Reaktion #161810

Reaktionsgleichung

1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-on-dihydrochloride

(6-chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone

DIPEA

→

1-{1-[6-(octahydroindole-1-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3-dihydroimidazo[4,5-b]pyridin-2-one

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurified by preparative HPLC-MS
2. 2
   Sonstigethe organic solvent was removed
3. 3
   Sonstigethe rotary evaporator
4. 4
   Sonstigethe precipitate obtained
5. 5
   Filtrationfiltered
6. 6
   WaschenThe precipitate was washed with water
7. 7
   Sonstigedried

Vorschrift

201 mg (0.69 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-on-dihydrochloride were added to 184 mg (0.69 mmol) (6-chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone and 488 μL (2.8 mmol) DIPEA in 3 mL DMF. The reaction mixture was stirred at RT over the weekend and then purified by preparative HPLC-MS. The product fractions were combined and the organic solvent was removed using the rotary evaporator. The aqueous solution was neutralised with aqueous 1N NaOH solution and the precipitate obtained was suction filtered. The precipitate was washed with water and dried.

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