Reaktion #161778

Reaktionsgleichung

trifluoroacetic anhydride

5-bromo-4-chloro-2-methylpyridine-1-oxide

MeOH

→

(5-bromo-4-chloro-pyridin-2-yl)-methanol

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas evaporated down
2. 2
   Extraktionextracted several times with EtOAC
3. 3
   SonstigeThe combined organic phases were dried on sodium sulphate
4. 4
   Sonstigeevaporated down

Vorschrift

3.0 mL trifluoroacetic anhydride were added dropwise at 10° C. to 2.6 g (12 mmol) 5-bromo-4-chloro-2-methylpyridine-1-oxide in 30 mL DCM. The reaction mixture was stirred for 5 days at RT. After the addition of MeOH the reaction mixture was evaporated down, the residue was combined with 15% potassium carbonate solution and extracted several times with EtOAC. The combined organic phases were dried on sodium sulphate and evaporated down.

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