Reaktion #161774

Reaktionsgleichung

m-chloroperbenzoic acid

(5-bromo-pyridin-3-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone

m-chloroperbenzoic acid

→

3-bromo-5-(5-fluoroindoline-1-carbonyl)pyridine-1-oxide

Lösungsmittel

DCM

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGwas stirred for 48 h at RT
2. 2
   Extraktionextracted with 1N aqueous sodium hydroxide solution
3. 3
   SonstigeThe organic phase was dried on sodium sulphate
4. 4
   Sonstigeevaporated down
5. 5
   Sonstigedried under HV

Vorschrift

0.19 g (1.1 mmol) m-chloroperbenzoic acid were added to 0.32 g (0.98 mmol) (5-bromo-pyridin-3-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone in 5.0 mL DCM and the mixture was stirred for 4 h at RT. In addition, a further 95 mg (0.55 mmol) m-chloroperbenzoic acid were added to the reaction mixture and it was stirred for 48 h at RT. Then the reaction mixture was diluted with DCM and extracted with 1N aqueous sodium hydroxide solution. The organic phase was dried on sodium sulphate, evaporated down and dried under HV.

Quelle