Reaktion #161766

Reaktionsgleichung

methyl 2-chloro-6-methanesulphonylamino-isonicotinate

lithium hydroxide

hydrochloric acid

→

2-chloro-6-methanesulphonylamino-isonicotinic acid

Lösungsmittel

tetrahydrofuran

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated down
2. 2
   SonstigeThe product was reacted without further purification

Vorschrift

0.29 g (1.1 mmol) methyl 2-chloro-6-methanesulphonylamino-isonicotinate in 5.0 mL tetrahydrofuran and 1 mL water were mixed with 79 mg (3.3 mmol) lithium hydroxide and stirred overnight at RT. The reaction mixture was acidified with 1M aqueous hydrochloric acid and evaporated down. The product was reacted without further purification.

Quelle