Reaktion #161765

Reaktionsgleichung

methyl 2,6-dichloro-isonicotinate

methanesulphonamide

potassium phosphate

Xantphos

→

methyl 2-chloro-6-methanesulphonylamino-isonicotinate

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through kieselguhr
2. 2
   Sonstigeevaporated down
3. 3
   Filtrationfiltered

Vorschrift

Under a nitrogen atmosphere 10 g (49 mmol) methyl 2,6-dichloro-isonicotinate, 5.6 g (59 mmol) methanesulphonamide, 14 g (68 mmol) potassium phosphate, 1.7 g (2.9 mmol) Xantphos and 0.90 g tris(dibenzylideneacetone)dipalladium in 300 mL dioxane were stirred for 5 h at 100° C. The mixture was suction filtered through kieselguhr and evaporated down. The residue was stirred with ethanol and the solid was suction filtered.

Quelle