Reaktion #1617223

Reaktionsgleichung

Diisopropyl ether

2-methyl-1,3-thiazole

2-[(aminooxy)sulfonyl]-1,3,5-trimethylbenzene

→

title compound

Ausbeute 63.0%

3-amino-2-methyl-1,3-thiazol-3-ium 2,4,6-trimethylbenzenesulfonate

Ausbeute 63.0%

Lösungsmittel

ethyl acetate toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   Filtrationthe resulting solid was collected by filtration

Vorschrift

To a solution of 2-methyl-1,3-thiazole (6.6 g, 67 mmol) in toluene (60 mL) was added a solution of 2-[(aminooxy)sulfonyl]-1,3,5-trimethylbenzene obtained in the above in ethyl acetate-toluene under ice-cooling, and the mixture was stirred for 2 hr. Diisopropyl ether (200 mL) was added to the reaction system, and the resulting solid was collected by filtration to give the title compound (13 g, 63%) as a white solid. The filtrate was concentrated under reduced pressure to about 100 mL, diisopropyl ether (100 mL) was added, and the resulting solid was collected by filtration to give the title compound (3.8 g, 18%) as a white solid (total yield 81%).

Quelle