Reaktion #1615524

Reaktionsgleichung

(2Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(phenyl)acetonitrile

hydroxylamine hydrochloride

potassium carbonate

→

(1Z,2Z)-2-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}-N′-hydroxy-2-phenylethanimidamide

Ausbeute 115.5%

Lösungsmittel

iPrOH H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated to ¾th
2. 2
   ExtraktionThe residue was extracted with EtOAc (3×50 ml)
3. 3
   Waschenwashed with aq. sat. NaCl
4. 4
   Trocknendried over MgSO4
5. 5
   Einengenconcentrated

Vorschrift

To a suspension of (2Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(phenyl)acetonitrile (4.5 g, 17.42 mmol, 1 eq.) in iPrOH/H2O (10/1, 110 ml) were added hydroxylamine hydrochloride (3.63 g, 52.26 mmol, 3 eq.) and potassium carbonate (7.22 g, 52.2 mmol, 3 eq.). The reaction was heated to 80° C. for 6 h and the solvent was evaporated to ¾th. The residue was extracted with EtOAc (3×50 ml) and washed with aq. sat. NaCl. The organics were combined, dried over MgSO4 and concentrated to give (1Z,2Z)-2-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}-N′-hydroxy-2-phenylethanimidamide (5.86 g) as a white solid.

Quelle