Reaktion #161509

Reaktionsgleichung

ethyl trifluoroacetate

allylamine

→

acetamide

N-allyl-2,2,2-trifluoroacetamide

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter the mixture was concentrated under reduced pressure
2. 2
   Sonstigethe residue was dried under vacuum

Vorschrift

To an ice-cold solution of ethyl trifluoroacetate (15 mL, 142.2 mmol) in THF (40 mL) was added allylamine (12 mL, 57.1 mmol). The reaction was allowed to warm to room temperature then stirred for 55 min. After the mixture was concentrated under reduced pressure, the residue was dried under vacuum to give acetamide 30. Yield (18.79 g, 98%): 1H NMR (400 MHz, CDCl3) δ 6.46 (br s, 1H), 5.79-5.89 (m, 1H), 5.23-5.29 (m, 2H), 3.98 (t, J=5.6 Hz, 2H).

Quelle