Reaktion #161492

Reaktionsgleichung

water

potassium carbonate

1-(2-aminoethyl)piperidine

2-(4-fluoro-3-nitrophenyl)benzoxazole

→

title compound

Ausbeute 94.0%

N-(2-(piperidin-1-yl)ethyl)-4-(benzoxazol-2-yl)-2-nitroaniline

Ausbeute 94.0%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthis was heated
2. 2
   Temperaturto reflux for 3 hours
3. 3
   Filtrationafter the precipitated crystals were filtered
4. 4
   Waschenwashed with water, they
5. 5
   Sonstigewere dried

Vorschrift

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (200 mg, 0.775 mmol) in acetonitrile (5 mL) was added potassium carbonate (214 mg, 1.55 mmol) and 1-(2-aminoethyl)piperidine (119 mg, 0.93 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (266 mg, 94% yield) as yellow crystals.

Quelle