Reaktion #161490

Reaktionsgleichung

potassium carbonate

5-(benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline

m-chlorobenzaldehyde

oxone

→

title compound

Ausbeute 94.0%

5-(benzoxazol-2-yl)-2-(3-chlorophenyl)-1-(tetrahydropyran-4-yl)benzimidazole

Ausbeute 94.0%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationafter this was filtered
2. 2
   Waschenwashed with water
3. 3
   Sonstigedrying

Vorschrift

To a solution of 5-(benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline (see Working Example 20-2) (150 mg, 0.485 mmol) in dimethylformamide (3 mL) was added m-chlorobenzaldehyde (81.8 mg, 0.582 mmol) and oxone (179 mg, 0.291 mmol), and this was stirred at room temperature for 2 hours. After the reaction was complete, aqueous potassium carbonate solution was added, and after this was filtered and washed with water, drying yielded the title compound (196 mg, 94% yield) as colorless crystals.

Quelle