Reaktion #161460

Reaktionsgleichung

water

benzoxazole

2-(2-(tetrahydrofuran-2-yl)methylaminoanilin-5-yl)benzoxazole

methyl acetimidate hydrochloride

→

title compound

Ausbeute 127.5%

5-(benzoxazol-2-yl)-2-methyl-1-(tetrahydrofuran-2-yl)methylbenzimidazole

Ausbeute 127.5%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthis was heated
2. 2
   Temperaturto reflux for 3 hours
3. 3
   TemperaturAfter the reaction solution was cooled
4. 4
   Filtrationthe precipitated crystals were filtered
5. 5
   Waschenafter being washed with water
6. 6
   Sonstigewere dried

Vorschrift

To a solution of 2-(tetrahydrofuran-2-yl)methylaminoanilin-5-yl)benzoxazole (see Working Example 95-1) (0.15 g, 0.4 mmol) in methanol (5 mL) was added methyl acetimidate hydrochloride (0.05 mg, 0.4 mmol), and this was heated to reflux for 3 hours. After the reaction solution was cooled, water was added, and the precipitated crystals were filtered, and after being washed with water were dried to yield the title compound (0.17 g, 79% yield) as white crystals.

Quelle