Reaktion #1614397

ord-d0c61bebff2e40fca8f8eaf1fdae1890

Reaktionsgleichung

O=Cc1c[nH]c2cc(OCc3ccccc3)ccc12
6-benzyloxy-1H-indole-3-carbaldehyde
NC(=O)c1cn(CC(=O)O)c2ccc(Cl)cc12
(3-carbamoyl-5-chloro-indol-1-yl)-acetic acid
→
NC(=O)c1cn(CC(=O)O)c2cc(OCc3ccccc3)ccc12
(6-Benzyloxy-3-carbamoyl-indol-1-yl)-acetic acid

Edukte

O=Cc1c[nH]c2cc(OCc3ccccc3)ccc12
6-benzyloxy-1H-indole-3-carbaldehyde
NC(=O)c1cn(CC(=O)O)c2ccc(Cl)cc12
(3-carbamoyl-5-chloro-indol-1-yl)-acetic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstige4.06 min.

Vorschrift

was prepared from 6-benzyloxy-1H-indole-3-carbaldehyde [92855-64-6] using similar protocols as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 325 [M+H]+, 649 [2M+H]+; tR (HPLC conditions b): 4.06 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09085555B2uspto-grants-2015_07