Reaktion #161288

Reaktionsgleichung

N-(1-acetylindolin-6-yl)-4-oxo-1H-quinoline-3-carboxamide

NaOH

→

N-indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide

Ausbeute 27.3%

N-Indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide

Ausbeute 27.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 48 h
3. 3
   EinengenThe solution was concentrated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in DMSO (1 mL)
5. 5
   Sonstigepurified by HPLC (10-99% CH3CN—H2O)

Vorschrift

A mixture of N-(1-acetylindolin-6-yl)-4-oxo-1H-quinoline-3-carboxamide (233) (43 mg, 0.12 mmol), 1N NaOH solution (0.5 mL) and ethanol (0.5 mL) was heated to reflux for 48 h. The solution was concentrated and the residue was dissolved in DMSO (1 mL) and purified by HPLC (10-99% CH3CN—H2O) to yield the product, N-indolin-6-yl-4-oxo-1H-quinoline-3-carboxamide (258) (10 mg, 20%). HPLC ret. time 2.05 min, 10-99% CH3CN, 5 min run; ESI-MS 306.3 m/z (MH+).

Quelle