Reaktion #161261

Reaktionsgleichung

ammonia

1-methyl-3,5-dinitro-2-pyridone

3-methyl-2-butanone

→

2-isopropyl-5-nitro-pyridine

Ausbeute 28.3%

Lösungsmittel

methyl alcohol

methyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under vacuum
2. 2
   workup.DISSOLUTIONthe residual oil was dissolved in CH2Cl2
3. 3
   Filtrationfiltered
4. 4
   TrocknenThe filtrate was dried over Na2SO4
5. 5
   Einengenconcentrated

Vorschrift

To a solution of 1-methyl-3,5-dinitro-2-pyridone (8.0 g, 40 mmol) in methyl alcohol (20 mL) was added dropwise 3-methyl-2-butanone (5.1 mL, 48 mmol), followed by ammonia solution in methyl alcohol (10.0 g, 17%, 100 mmol). The reaction mixture was heated at 70° C. for 2.5 h under atmospheric pressure. The solvent was removed under vacuum and the residual oil was dissolved in CH2Cl2, and then filtered. The filtrate was dried over Na2SO4 and concentrated to afford 2-isopropyl-5-nitro-pyridine (1.88 g, 28%).

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