Reaktion #1612368

Reaktionsgleichung

(R)-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-2′,6-diamine

5-cyanopicolinic acid

→

title compound

Ausbeute 78.0%

(R)—N-(2′-Amino-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-6-yl)-5-cyanopicolinamide

Ausbeute 78.0%

Reaktionsbedingungen

Vorschrift

The condensation of (R)-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-2′,6-diamine (intermediate B7.3) and 5-cyanopicolinic acid yielded the title compound (78% yield) as a yellow solid. MS (ISP): m/z=428.3 [M+H]+.

Quelle