Reaktion #1612366

Reaktionsgleichung

(R)-5′,5′-difluoro-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-2′,6-diamine

4-chloro-1H-pyrazole-5-carboxylic acid

→

title compound

Ausbeute 34.0%

(R)—N-(2′-Amino-5′,5′-difluoro-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-6-yl)-5-cyanopicolinamide

Ausbeute 34.0%

Reaktionsbedingungen

Vorschrift

The condensation of (R)-5′,5′-difluoro-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-2′,6-diamine (intermediate B7.1) and 4-chloro-1H-pyrazole-5-carboxylic acid yielded the title compound (34% yield) as a pale yellow solid. MS (ISP): m/z=398.1 [M+H]+.

Quelle