Reaktion #1612359

Reaktionsgleichung

(R)-6-bromo-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

intermediate B6.5

(R)-6-bromo-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

5-chloropyridin-3-ylboronic acid

→

title compound

Ausbeute 78.0%

(R)-6-(5-chloropyridin-3-yl)-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

Ausbeute 78.0%

Reaktionsbedingungen

Vorschrift

In a manner analogous to that described in Example 19, the cross coupling reaction of (R)-6-bromo-5′,5′-difluoro-2,2-dimethyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine (intermediate B6.5) with 5-chloropyridin-3-ylboronic acid yielded the title compound (78% yield) as a white powder. MS (ISP): m/z=394.1 [M+H]+.

Quelle