Reaktion #1612357

Reaktionsgleichung

(2RS,4R)-6-bromo-5′,5′-difluoro-2-phenyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

pyrimidin-5-ylboronic acid

→

title compound

Ausbeute 22.0%

(2RS,4R)-5′,5′-difluoro-2-phenyl-6-(pyrimidin-5-yl)-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

Ausbeute 22.0%

Reaktionsbedingungen

Vorschrift

In a manner analogous to that described in Example 19, the cross coupling reaction of (2RS,4R)-6-bromo-5′,5′-difluoro-2-phenyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine (intermediate B6.3) with pyrimidin-5-ylboronic acid yielded the title compound (22% yield) as a white solid. MS (ISP): m/z=409.3 [M+H]+.

Quelle