Reaktion #1612356

Reaktionsgleichung

(2RS,4R)-6-bromo-5′,5′-difluoro-2-phenyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine

5-cyanopyridin-3-ylboronic acid

→

title compound

Ausbeute 16.0%

5-((2RS,4R)-2′-amino-5′,5′-difluoro-2-phenyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazine]-6-yl)nicotinonitrile

Ausbeute 16.0%

Reaktionsbedingungen

Vorschrift

In a manner analogous to that described in Example 19, the cross coupling reaction of (2RS,4R)-6-bromo-5′,5′-difluoro-2-phenyl-5′,6′-dihydrospiro[chroman-4,4′-[1,3]oxazin]-2′-amine (intermediate B6.3) with 5-cyanopyridin-3-ylboronic acid yielded the title compound (16% yield) as a white solid. MS (ISP): m/z=433.3 [M+H]+.

Quelle