Reaktion #1612340

Reaktionsgleichung

1,2-dimethoxyethane

(R)-6-bromo-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazin]-2′-amine

5-cyanopyridin-3-ylboronic acid

→

title compound

(R)-5-(2′-Amino-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazine]-6-yl)nicotinonitrile

Lösungsmittel

water

Reaktionsbedingungen

Vorschrift

In a manner analogous to that described in Example 1, the cross-coupling reaction of (R)-6-bromo-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazin]-2′-amine (intermediate A6.5) with 5-cyanopyridin-3-ylboronic acid in a 3:1-mixture of 1,2-dimethoxyethane and water as the solvent yielded the title compound as an off-white solid.

Quelle