Reaktion #161234

Reaktionsgleichung

H2O

Et3N

mercapto-acetic acid

1-chloro-2,4-dinitrobenzene

→

2-(2,4-dinitrophenylthio)-acetic acid

Ausbeute 89.1%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe resulting suspension was extracted with ethyl acetate (100 mL×3)
2. 2
   ExtraktionThe ethyl acetate extract
3. 3
   Waschenwas washed with water and brine
4. 4
   Trocknendried over Na2SO4
5. 5
   Einengenconcentrated

Vorschrift

Et3N (1.5 g, 15 mmol) and mercapto-acetic acid (1 g, 11 mmol) were added to a solution of 1-chloro-2,4-dinitrobenzene (2.26 g, 10 mmol) in 1,4-dioxane (50 mL) at room temperature. After stirring at room temperature for 5 h, H2O (100 mL) was added. The resulting suspension was extracted with ethyl acetate (100 mL×3). The ethyl acetate extract was washed with water and brine, dried over Na2SO4 and concentrated to give 2-(2,4-dinitrophenylthio)-acetic acid (2.3 g, 74%), which was used without further purification.

Quelle