Reaktion #1612339

Reaktionsgleichung

1,2-dimethoxyethane

(R)-6-bromo-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazin]-2′-amine

3-cyanophenylboronic acid

→

title compound

Ausbeute 10.0%

(R)-3-(2′-Amino-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazine]-6-yl)benzonitrile

Ausbeute 10.0%

Lösungsmittel

water

Reaktionsbedingungen

Vorschrift

In a manner analogous to that described in Example 1, the cross-coupling reaction of (R)-6-bromo-5′,5′-difluoro-2,3,5′,6′-tetrahydrospiro[indene-1,4′-[1,3]oxazin]-2′-amine (intermediate A6.5) with 3-cyanophenylboronic acid in a 3:1-mixture of 1,2-dimethoxyethane and water as the solvent yielded the title compound (10% yield) as an off-white solid. MS (ISP): m/z=340.2 [M+H]+.

Quelle