Reaktion #161085

Reaktionsgleichung

2,4-dichloroquinoline

MeOH

sodium methoxide

→

2,4-dimethoxyquinoline

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturat reflux for 2 days
3. 3
   TemperaturAfter cooling
4. 4
   Filtrationthe mixture was filtered
5. 5
   EinengenThe filtrate was concentrated under reduced pressure
6. 6
   Sonstigeto yield a residue that
7. 7
   Extraktionextracted with CH2Cl2
8. 8
   TrocknenThe combined organic layers were dried over Na2SO4
9. 9
   Einengenconcentrated

Vorschrift

To a suspension of 2,4-dichloroquinoline in MeOH (100 mL) was added sodium methoxide (50 g). The mixture was heated at reflux for 2 days. After cooling, the mixture was filtered. The filtrate was concentrated under reduced pressure to yield a residue that was dissolved in water and extracted with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated to give 2,4-dimethoxyquinoline as a white solid (13 g, 74% over 2 steps).

Quelle