Reaktion #161082

Reaktionsgleichung

2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester

diphenylether

→

4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester

Lösungsmittel

n-hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 15 min
2. 2
   TemperaturAfter cooling
3. 3
   SonstigeThe resulting solid was isolated via filtration
4. 4
   Sonstigerecrystallized from methanol

Vorschrift

A mixture of 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (2.8 g, 1 mmol) and diphenylether (20 mL) was refluxed for 15 min. After cooling, n-hexane (80 mL) was added. The resulting solid was isolated via filtration and recrystallized from methanol to give 4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (1.7 g 72%).

Quelle