Reaktion #161065

Reaktionsgleichung

2-(1H-pyrrol-2-yl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one

L-valinol

ethyl acetate

→

title compound

Ausbeute 76.4%

N-[[1-[[(1H-Pyrrol-2-yl)carbonyl]amino]cyclohexyl]carbonyl]-L-valinol

Ausbeute 76.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe reaction solution was distilled off under reduced pressure
2. 2
   Sonstigethe residue was purified by silica gel chromatography

Vorschrift

220 mg (1.01 mmol) of 2-(1H-pyrrol-2-yl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one was added to a solution of 252 mg (2.45 mmol) of L-valinol in 5 ml of ethyl acetate, and the mixture was stirred at room temperature for 4 days. The reaction solution was distilled off under reduced pressure and the residue was purified by silica gel chromatography to obtain 247 mg (76.4%) of the title compound.

Quelle