Reaktion #161064

Reaktionsgleichung

2-(4-methoxyphenyl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one

L-valinol

ethyl acetate

→

title compound

Ausbeute 66.7%

N-[[1-[[(4-Methoxyphenyl)carbonyl]amino]cyclohexyl]carbonyl]-L-valinol

Ausbeute 66.7%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe reaction solution was distilled off under reduced pressure
2. 2
   Waschenthe residue was washed with diethyl ether

Vorschrift

260 mg (1.00 mmol) of 2-(4-methoxyphenyl)-3-oxo-1-azaspiro[4.5]dec-1-en-4-one was added to a solution of 252 mg (2.45 mmol) of L-valinol in 5 ml of ethyl acetate, and the mixture was stirred at room temperature for 4 days. The reaction solution was distilled off under reduced pressure, and the residue was washed with diethyl ether to obtain 243.5 mg (66.7%) of the title compound.

Quelle