Reaktion #161063

ord-2f1ffac19e114f4d97b2ad5ddb4635e3

Reaktionsgleichung

O=C(NC1(C(=O)O)CCCCC1)OCc1ccco1
1-[[(2-furanylmethoxy)carbonyl]amino]cyclohexanecarboxylic acid
CC(C)[C@H](N)CO
L-valinol
CC(C)[C@@H](CO)NC(=O)C1(NC(=O)OCc2ccco2)CCCCC1
title compound
CC(C)[C@@H](CO)NC(=O)C1(NC(=O)OCc2ccco2)CCCCC1
N-[[1-[[(2-Furanylmethoxy)carbonyl]amino]cyclohexyl]carbonyl]-L-valinol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2.00 g (7.48 mmol) of 1-[[(2-furanylmethoxy)carbonyl]amino]cyclohexanecarboxylic acid was used instead of 2-benzothiophenecarboxylic acid, and 772 mg (7.48 mmol) of L-valinol was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester in the process according to Reference Example 197 to obtain 2.67 g (quantitative) of the title compound and 2.64 g (quantitative) of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08829209B2uspto-grants-2014_09