Reaktion #161052

Reaktionsgleichung

L-methioninol

2-(2-benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one

Water

→

title compound

Ausbeute 98.1%

N-[[1-[(2-Benzothienylcarbonyl)amino]cyclohexyl]carbonyl]-L-methioninol

Ausbeute 98.1%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitated crystal was collected by filtration
2. 2
   SonstigeThe obtained crystal was dried under reduced pressure

Vorschrift

284 mg (2.1 mmol) of L-methioninol was added to a solution of 500 mg (1.75 mmol) of 2-(2-benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one in 3 ml of N,N-dimethylformamide, and the mixture was stirred overnight. Water was slowly added and the precipitated crystal was collected by filtration. The obtained crystal was dried under reduced pressure to obtain 722 mg (98%) of the title compound.

Quelle