Reaktion #161003

ord-cd5431c4d51b45cdbf340916e98431de

Reaktionsgleichung

CCOC(=O)C1(N)CCCCC1.Cl
1-aminocyclohexanecarboxylic acid ethyl ester hydrochloride
O=C(O)c1cc2ccccc2o1
benzofuran-2-carboxylic acid
CCOC(=O)C1(NC(=O)c2cc3ccccc3o2)CCCCC1
title compound
Ausbeute 80.3%
CCOC(=O)C1(NC(=O)c2cc3ccccc3o2)CCCCC1
1-[(2-Benzofuranylcarbonyl)amino]cyclohexanecarboxylic acid ethyl ester
Ausbeute 80.3%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3.11 g (15 mmol) of 1-aminocyclohexanecarboxylic acid ethyl ester hydrochloride was used instead of 1-aminocyclohexanecarboxylic acid methyl ester hydrochloride, and 2.43 g (15 mmol) of benzofuran-2-carboxylic acid was used instead of 3-furancarboxylic acid in the process according to Reference Example 15 to obtain 3.80 g (80%) of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08829209B2uspto-grants-2014_09