Reaktion #160786

Reaktionsgleichung

(S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate

2-bromothiazole-4-carboxylic acid

HOAT

EDC

→

(S)-tert-butyl 1-(3-(2-bromothiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate

Lösungsmittel

EtOAc

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwas washed with H2O (4×), NaCl(sat.)
2. 2
   Trocknenwas dried over MgSO4
3. 3
   Filtrationwas filtered
4. 4
   Sonstigethe volatiles were removed in vacuo

Vorschrift

A solution containing 1 eq each of (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate, 2-bromothiazole-4-carboxylic acid, HOAT and EDC in DMF, at a concentration of 0.5 M, was stirred for 60 hours. The solution was diluted with EtOAc and was washed with H2O (4×), NaCl(sat.), was dried over MgSO4, was filtered and the volatiles were removed in vacuo yielding (S)-tert-butyl 1-(3-(2-bromothiazole-4-carboxamido)pyridin-4-yl)piperidin-3-ylcarbamate, LCMS (m/z): 416.1 (MH+); LC Rt=1.95 min.

Quelle