Reaktion #160782

Reaktionsgleichung

HCl

ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate

LiOH

→

2-(2,6-difluorophenyl)thiazole-4-carboxylic acid

Ausbeute 88.0%

Lösungsmittel

THF MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe THF/MeOH was removed in vacuo
2. 2
   FiltrationThe resulting solid was filtered
3. 3
   Waschenrinsed with H2O
4. 4
   Sonstigedried

Vorschrift

To a solution of ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate (1.0 eq.) in 2:1 THF/MeOH (0.17 M) was added 1.0 M LiOH (2.0 eq.). After standing for 16 hours, 1.0 M HCl (2.0 eq.) was added and the THF/MeOH was removed in vacuo. The resulting solid was filtered, rinsed with H2O and dried, yielding 2-(2,6-difluorophenyl)thiazole-4-carboxylic acid (88%) as a crusty solid. LCMS (m/z): 251.1 (MH+); LC Rt=2.68 min.

Quelle